Application of xanthene derivatives for analytical chemistry. Part XXVI. Spectrophotometric determination of chlorpromazine hydrochloride using the color reaction with palladium(II) and o-hydroxyhydroquinonephthalein.

1 January 1983

journal article
Published by Japan Society for Analytical Chemistry in BUNSEKI KAGAKU

Vol. 32 (1) , E1-E7
https://doi.org/10.2116/bunsekikagaku.32.e1

Abstract

A color reaction among chlorpromazine hydrochloride(CP.HCl), palladium(II) and o-hydroxyhydroquinonephthalein(Qn. Ph.) in the presence of sodium dodecylsulfate(SDS) -chloride ions was studied, and a simple and rapid spectrophotometric method for the determination of CP.HCl has been established. This proposed method could be used in the concentration range of 0 - 150μg/10ml of CP. HCl, where the apparent molar absorptivity was calculated to be 2.2×10⁴ l mol^-1cm^-1 at 525nm, and was applied successfully to the determination of CP. HCl in pharmaceutical preparations.

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