Prostaglandins in the umbilical and uterine circulations during late pregnancy in the ewe

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Abstract
Prostaglandin(PG)E, PGF and 13,15-dihydro-15-keto-prostaglandin F (PGFM) were measured in plasma collected from the umbilical artery and vein, the maternal carotid artery and the utero-ovarian vein of pregnant sheep from gestation day 116-139. PGE levels were greater than PGF levels in the umbilical artery and vein and the maternal carotid artery, but not in the utero-ovarian vein. PGFM exceeded PGF in samples from all vessels. There was a significant vein-to-artery concentration difference for PGF and PGFM, but not for PGE, in the umbilical circulation. Utero-ovarian concentrations of all 3 PG generally exceeded their concentrations in the maternal carotid artery.