OESTROGEN-INDUCED PROTEIN IN RAT MAMMARY TUMOUR AND UTERUS
- 1 November 1977
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 75 (2) , 331-332
- https://doi.org/10.1677/joe.0.0750331
Abstract
Biology Unit, Institute of Interdisciplinary Research, Free University of Brussels, 115 B Waterloo, 1000-Brussels, Belgium and *Service de Médecine et Laboratoire d'Investigation Clinique, Institut J. Bordet, 1000-Brussels, Belgium (Received 19 April 1977) We wish to report evidence for the early induction by oestradiol-17β of a protein in mammary tumours induced in Sprague–Dawley rats by 7,12-dimethylbenz(a)anthracene (DMBA). The protein appears to be analogous to the oestrogen-induced protein first discovered in the rat uterus by Notides & Gorski (1966) and widely known as 'induced protein' (IP). Induction of IP by oestradiol-17β has been demonstrated in rodents in several tissues of the female genital tract that are targets for oestrogens (Katzman, Larson & Podratz, 1971; Katzenellenbogen & Leake, 1974; Dupont-Mairesse & Galand, 1975) and correlated with the rate of nuclear accumulation of oestrogen receptors (Katzenellenbogen & Gorski, 1972; Katzenellenbogen, 1975). Therefore, the search for induction of IP in DMBA-induced mammary tumours containing oestrogenThis publication has 1 reference indexed in Scilit:
- Estrogen-induced synthesis of a specific uterine protein.Proceedings of the National Academy of Sciences, 1966