The Pattern of Recovery of Erythropoiesis in Heavily Irradiated Mice Receiving Transplants of Fetal Liver

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Abstract
The recovery of erythropoiesis in heavily irradiated mice receiving fetal liver was compared with that of mice receiving adult bone marrow. The number of cells was adjusted so that each group received a comparable number of cfu. Red cell production as judged by both iron incorporation and peripheral reticulocyte values began earlier in the fetal liver transplant than after adult bone marrow. Further, the extent of erythroid colonization of the bone marrow appeared greater in recipients of fetal tissue than adult. These differences in the recovery pattern suggest that stem cell regulation of fetal erythropoiesis differs from that of the adult.