Effects of Hypophysectomy and Prolactin Replacement Therapy on Prostatic Response to Androgen in Orchiectomized Rats
- 1 November 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Biology of Reproduction
- Vol. 17 (4) , 489-492
- https://doi.org/10.1095/biolreprod17.4.489
Abstract
When rats castrated on Day minus 23 (D-23) are hypophysectomized (D-13) and treated with testosterone propionate (1.0 mg every other day for 16 days; (D-0 is the first day of testosterone propionate treatment) the body weight, prostatic weight and citric acid level of the prostate decrease more than those of testosterone-treated, castrated, sham-hypophysectomized rats. Such observations imply the involvement of a pituitary factor in the maintenance of prostatic integrity. More direct evidence is obtained when prolactin replacement therapy (50 units daily for the last 13 days) in hypophysectomized, castrated, testosterone-treated rats increases the prostatic weight and both content and concentration of citric acid significantly and the body weight slightly.Keywords
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