The Suppressor-Cell Network in Cancer

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Abstract
(Second of Two Parts)Suppressor Cells in the Enhancement of Tumor GrowthOncogenesis is accompanied by the appearance of tumor-associated cellular neoantigens in a large number of carefully studied models. The immuno-competent cells of the host can frequently recognize these antigens as "non-self" surface antigens and, under some conditions, can inhibit tumor progression. However, in many instances the tumor grows in spite of its "non-self" antigens and an apparent host immune response. For a number of years, the ineffectual immune response of tumor-bearing hosts was ascribed to the presence of circulating-blocking factors thought to impede the neutralization of tumor cells . . .