Effect of Anatomical Distribution of Mast Cells on Their Defense Function against Bacterial Infections
Open Access
- 27 May 2003
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 197 (11) , 1417-1425
- https://doi.org/10.1084/jem.20022157
Abstract
Mast cells were depleted in the peritoneal cavity of WBB6F1-tg/tg mice that did not express a transcription factor, MITF. When acute bacterial peritonitis was induced in WBB6F1-+/+, WBB6F1-W/Wv, and WBB6F1-tg/tg mice, the proportion of surviving WBB6F1-+/+ mice was significantly higher than that of surviving WBB6F1-W/Wv or WBB6F1-tg/tg mice. The poor survival of WBB6F1-W/Wv and WBB6F1-tg/tg mice was attributed to the deficient influx of neutrophils into the peritoneal cavity. The injection of cultured mast cells (CMCs) derived from WBB6F1-+/+ mice normalized the neutrophil influx and reduced survival rate in WBB6F1-W/Wv mice, but not in WBB6F1-tg/tg mice. This was not attributable to a defect of neutrophils because injection of TNF-α increased the neutrophil influx and survival rate in both WBB6F1-W/Wv and WBB6F1-tg/tg mice. Although WBB6F1-+/+ CMCs injection normalized the number of mast cells in both the peritoneal cavity and mesentery of WBB6F1-W/Wv mice, it normalized the number of mast cells only in the peritoneal cavity of WBB6F1-tg/tg mice. Mast cells within the mesentery or mast cells in the vicinity of blood vessels appeared to play an important role against the acute bacterial peritonitis. WBB6F1-tg/tg mice may be useful for studying the effect of anatomical distribution of mast cells on their antiseptic function.Keywords
This publication has 46 references indexed in Scilit:
- Dual abnormal effects of mutant MITF encoded by Miwh allele on mouse mast cells: decreased but recognizable transactivation and inhibition of transactivationBiochemical and Biophysical Research Communications, 2002
- Effect of a large deletion of the basic domain of mitranscription factor on differentiation of mast cellsBlood, 2001
- Importance of leucine zipper domain of mitranscription factor (MITF) for differentiation of mast cells demonstrated using mice/mice mutant mice of which MITF lacks the zipper domainBlood, 2001
- Independent Influence of Strain Difference and mi Transcription Factor on the Expression of Mouse Mast Cell ChymasesThe American Journal of Pathology, 2001
- Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-αNature, 1996
- Critical protective role of mast cells in a model of acute septic peritonitisNature, 1996
- Loss of DNA Binding Ability of the Transcription Factor Encoded by the Mutant mi LocusBiochemical and Biophysical Research Communications, 1994
- The kit ligand: A cell surface molecule altered in steel mutant fibroblastsCell, 1990
- Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells.The Journal of Experimental Medicine, 1985
- Berberine sulphate binding to mast cell polyanions: A cytofluorometric method for the quantitation of heparinHistochemistry and Cell Biology, 1974