Monoamine Oxidases: the Present Status

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Abstract
The multiplicity of the insoluble mitochondrial enzyme, monoamine oxidase, has now been demonstrated in a variety of ways, indirectly by the use of selective inhibitors or directly (after solubilization), employing electrophoretic or immunochemical methods of separation. Although data obtained by these approaches may differ and are sometimes difficult to reconcile, evidence is continuing to accrue that the multiple forms are a true in vivo phenomenon and not merely preparation artefacts. Their functional significance and possible role in depressive illness have yet to be decided.

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