A Convenient Method for the Conversion of N-Acyloxazolidinones to Hydroxamic Acids
- 11 September 2002
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (20) , 3343-3346
- https://doi.org/10.1021/ol0263301
Abstract
Treatment of N-acyloxazolidinones with hydroxylamines using samarium triflate as a Lewis acid provides the corresponding hydroxamic acids in 50−98% yields at room temperature. The conversion proceeds with high degree of chemoselectivity and without racemization of chiral centers α- to the acyl group.Keywords
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