A reactive multi-target sputtering method was applied to prepare epitaxial (Pb, La)TiO3 thin films on sapphire. The individual control of each sputtering target revealed that the incident Pb content remarkably influenced the quality of thin film. The strict control of (Pb, La)TiO3 composition was carried out and strong electro-optic effect was observed in (Pb0.74La0.26)Ti0.94 O3 thin film.