THE EFFECT OF ACIDOSIS UPON THE RENAL TUBULAR REABSORPTION OF PHOSPHATE

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Abstract
The renal excretion of phosphate was studied in dogs in which an acidosis was produced by the oral adm. of ammonium chloride. Simultaneous detns. of the plasma phosphate and creatinine clearances were made following the inj. of a standard dose of Na phosphate. The rate of reabsorption of phosphate by the renal tubules was estimated by the difference between the phosphate and creatinine clearances. Following the production of an acidosis the rate of reabsorption of phosphate by the renal tubules was decreased. The extent of the decrease was a function of both the severity and duration of the acidosis. The decreased conc. of phosphate in the plasma found following the adm. of acidifying salts can be explained by this effect on the renal tubular reabsorption of phosphate.

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