CYSTEINE-RICH REGIONS CONSERVED IN AMINO-TERMINAL HALVES OF RAF GENE FAMILY PRODUCTS AND PROTEIN-KINASE-C

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  • 1 December 1986
    • journal article
    • research article
    • Vol. 77  (12) , 1183-1187
Abstract
The predicted amino acid sequences of rat c-raf and A-raf products were subjected to homology search against other known amino acid sequences. We found that characteristic, cysteine-rich regions present in the amino-terminal halves of c-raf and A-raf products had striking homologies with the cysteine-rich regions present in protein kinase C. These cysteine-rich regions had been shown to be deleted in the activated raf products and in the catalytically active protein kinase C produced by proteolysis. These facts suggest the significance of the cysteine-rich regions of raf products as well as those of protein kinase C in the regulation of kinase activities.