TRANSMISSION IN THE SQUID GIANT SYNAPSE - A MODEL BASED ON VOLTAGE CLAMP STUDIES

  • 1 January 1980
    • journal article
    • research article
    • Vol. 76  (5) , 413-418
Abstract
Voltage clamp studies were performed in squid giant synapse after blockage of the voltage-dependent Na and K conductances. Presynaptic depolarization under these conditions demonstrates the presence of voltage-dependent Ca conductance change for the duration of the voltage step, and a tail current at the break of the pulse. This Ca current triggers a postsynaptic response which can be measured directly at the postsynaptic fiber. These voltage clamp experiments have allowed the development of a mathematical model that describes the kinetics of the Ca current, and the relationship between Ca current and transmitter release.

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