Chronic Idiopathic Jaundice with Normal Liver Histology

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Abstract
In recent years there have been numerous reports and reviews of the various kinds of familial, nonhemolytic and nonobstructive hyperbilirubinemia in the adult. Basically, these cases can be divided into two main categories. The first group is made up of those cases in whom the elevated bilirubin is mainly unconjugated (indirect), and they, consequently, have no bile in the urine. Gilbert et al.1-3 described a group of patients in this category, and since then there have been numerous reviews of this syndrome published under a variety of names.4-8 The second group is composed of patients who have elevated levels of both conjugated (direct) and unconjugated (indirect) bilirubin in their serum. These patients frequently have bilirubinuria. Patients of this variety were first described by Dubin and Johnson9 and Sprinz and Nelson,10 and a rather extensive review of this syndrome (chronic idiopathic jaundice or the Dubin-Johnson syndrome) appeared

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