Movement of necrotic wavefront after coronary artery occlusion in rabbit

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Abstract
Movement of the necrotic wavefront after coronary artery occlusion (CAO) was defined in rabbits by comparing transient CAO (15, 30 or 60 min) and reperfusion to permanent CAO (n = 5-9/group). At 24 h after CAO the area of necrosis was determined by nitroblue tetrazolium staining, and the transmural and circumferential extent of necrosis was evaluated at 4 levels from ligation to apex. Infarct size after permanent CAO for 24 h was 27 .+-. 2% (SE) of the left ventricle. Reperfusion at 60, 30 or 15 min after CAO reduced the infaract size to 24 .+-. 3 (P = NS [not significant] vs. 24 h), 14 .+-. 2 and 8 .+-. 1% ( P < 0.05 vs. 60 min), respectively. Reperfusion at 15 and 30 min after CAO decreaed transmural extent by 49 and 38% (P < 0.001 vs. 24 h) whereas the circumferential extent was reduced by only 10 and 12%, respectively (P = NS). After 60 min of CAO, reperfusion did not significantly reduce either transmural or circumferential necrosis. Early reperfusion reduced infarct size by converting potentially transmural infarcts into subendocardial infarcts but did not significantly reduce the lateral or circumferential extent of necrosis.