Dopamine Modulation of Prefrontal Cortical Interneurons Changes during Adolescence
Open Access
- 13 June 2006
- journal article
- research article
- Published by Oxford University Press (OUP) in Cerebral Cortex
- Vol. 17 (5) , 1235-1240
- https://doi.org/10.1093/cercor/bhl034
Abstract
Adolescence is marked by profound psychological and neuroendocrine changes. Cognitive functions that depend on the prefrontal cortex and dopamine (DA), such as decision making, are acquired or refined during adolescence; yet, little is known about how neural circuits mature in the transition to adulthood. Here, we conducted electrophysiological recordings in rat brain slices, unveiling an enhancement of the excitability of interneurons, which are important for cortical network activity, by D1 and D2 DA receptors. The D2 effect was observed in slices from adult (postnatal day [PD] > 50) but not preadolescent (PD < 36) animals suggesting a possible neural substrate for the maturation of DA-dependent prefrontal cortical functions during or after adolescence and identifying a critical neural population that could be involved in the periadolescent onset of neuropsychiatric disorders, such as schizophrenia.Keywords
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