STIMULATION OF ANTIBODY-SYNTHESIS INDUCED BY SURGICAL TRAUMA IN RATS
- 1 January 1978
- journal article
- research article
- Vol. 32 (2) , 243-252
Abstract
The effect of a standard laparotomy on antibody synthesis was studied in Wistar R/A rats receiving an i.v. injection of 109 sheep red blood cells (SRBC) during the surgical procedure. Anti-SRBC antibody titers were significantly higher in operated animals than in controls. When SRBC were given 2 h after the surgical procedure, stimulation of antibody synthesis still persisted, but when the antigen was administered 24 h after laparotomy, no significant difference was detected between the operated animals and controls. Surgery also enhances the secondary humoral response.This publication has 16 references indexed in Scilit:
- Anesthesia and immunology.1976
- Acquired immunologic deficiencies after trauma and surgical procedures.1974
- Depression of immunological responses due to surgery. A model in the guinea-pig.1974
- Plaque Forming Cells: Methodology and TheoryImmunological Reviews, 1974
- Lack of correlation between the effects of cortisone on mouse spleen plaque-forming cells and circulating anti-sheep red blood cell haemolysins.1973
- International agreement on a microtechnique of platelet complement fixation (Pl. C fix.).1971
- The effects of surgery and anesthesia on the immunologic responsiveness of the rat.1969
- Alterations of the Immune Response Following Severe Thermal InjuryArchives of Surgery, 1966
- Antibody production after certain forms of trauma.1956
- The Effect of Severe Battle Injury and of Post-Traumatic Renal Failure on Resistance to InfectionAnnals of Surgery, 1955