Study of erythromycin A decomposition products in aqueous solution by solid-phase microextraction/liquid chromatography/tandem mass spectrometry
- 14 February 1998
- journal article
- research article
- Published by Wiley in Rapid Communications in Mass Spectrometry
- Vol. 12 (3) , 123-129
- https://doi.org/10.1002/(sici)1097-0231(19980214)12:3<123::aid-rcm126>3.0.co;2-4
Abstract
The decomposition of erythromycin A (EA) in aqueous solution was examined in the pH range 2–13 by means of combined solid‐phase microextraction (SPME) and liquid chromatography/electrospray ionization tandem mass spectrometry. Degradation of EA, especially at lower pH values (pH ≤ 3), was very rapid and yielded a wide variety of decomposition products. Identification of these degradation products was achieved by means of tandem mass spectrometry in the product ion and precursor ion scan modes. Anhydroerythromycin A was shown to be the major reaction product in both acidic and basic solutions. Among the different SPME fibers investigated for extraction from aqueous solutions, polydimethylsiloxane/divinylbenzene exhibited the best performance for EA and its degradation products. © 1998 John Wiley & Sons, Ltd.Keywords
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