Evidence for a Halothane‐Dependent Cyclic Flux of Calcium in Rat‐Liver Mitochondria

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Abstract
The previously reported (Hall et al., Biochem. Soc. Trans. 1973) halothane-dependent, calcium-induced loss of respiratory control in rat liver mitochondria is relatively specific to calcium; the effect of strontium ions is much smaller, and comparable additions of potassium salts have no effect on mitochondrial respiration on succinate in the presence of halothane. The calcium-dependent loss of respiratory control can be prevented, or reversed, respectively, by the prior or subsequent addition of agents that either chelate extramitochondrial Ca2plus or inhibit calcium accumulation, or that inhibit the efflux of accumulatec calcium. These results suggest that the halothane-dependent, calcijm-induced loss of respiratory control is due to a cyclic flux of calcium uptake and release.