Nonlinear Dependence of Fish Bioconcentration on n-Octanol/Water Partition Coefficient
Open Access
- 1 March 1993
- journal article
- research article
- Published by Taylor & Francis in SAR and QSAR in Environmental Research
- Vol. 1 (1) , 29-39
- https://doi.org/10.1080/10629369308028814
Abstract
The log-log relationship between the bioconcentration tendency of organic chemicals in fish and the n−octanol/water partition coefficients breaks down for very hydrophobic compounds. The use of parabolic and bilinear models allows this problem to be overcome. The QSAR equation log BCF = 0.910 log P - 1.975 log (6.8 10−7 P + 1) - 0.786 (n = 154; r = 0.950; s = 0.347; F = 463.51) was found to be a good predictor of bioconcentration in fish.Keywords
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