l-Homoserine Fermentation

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Abstract
In the course of studies on “negative feedback control” mechanisms caused by threonine and methionine in l-homoserine fermentation with Micrococcus glutamicus 534-Co147 culture, l-homoserine dehydrogenase was first found to occur in the culture, and effects of various amino acids on the formation and action of the enzyme were then investigated. The result was that l-homoserine dehydrogenase of the culture was repressed by methionine on the one hand, and inhibited by threonine on the other. β-Aspartokinase was found not to be repressed by methionine. From these findings, the sites at which the “negative feedback control” mechanisms work were discussed.
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