Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by Human Liver Carboxylesterase

This publication has 13 references indexed in Scilit:

• Reversed-phase high-performance liquid chromatographic method for the simultaneous quantitation of the carboxylate and lactone forms of the camptothecin derivative irinotecan, CPT-11, and its metabolite SN-38 in plasma
  Journal of Chromatography B: Biomedical Sciences and Applications, 1994
• Metabolic Activation of CPT-11, 7-Ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycamptothecin, a Novel Antitumor Agent, by Carboxylesterase.
  Biological & Pharmaceutical Bulletin, 1994
• The Current Status of Camptothecin Analogues as Antitumor Agents
  JNCI Journal of the National Cancer Institute, 1993
• Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives: Carbamate-Linked, Water-Soluble Derivatives of 7-Ethyl-10-hydroxycamptothecin.
  CHEMICAL & PHARMACEUTICAL BULLETIN, 1991
• CPT-11 Converting Enzyme from Rat Serum: Purification and Some Properties.
  Journal of Pharmacobio-Dynamics, 1991
• Purification and characterization of two human liver carboxylesterases
  International Journal of Biochemistry, 1989
• Human liver carboxylesterase
  Archives of Biochemistry and Biophysics, 1974
• Carboxylesterases (EC 3.1.1). Kinetic studies on carboxylesterases
  Biochemistry, 1969
• Carboxylesterases (EC 3.1.1.). The molecular weight and equivalent weight of pig liver carboxylesterase
  Biochemistry, 1969
• THEORY OF THE TRANSIENT PHASE IN AN ENZYME SYSTEM INVOLVING TWO ENZYME-SUBSTRATE COMPLEXES: THE CASE OF THE FORMATION OF PRODUCTS FROM THE FIRST COMPLEX
  Canadian Journal of Chemistry, 1959