How Sound Is the Double-Blind Design for Evaluating Psychotropic Drugs?
- 1 June 1993
- journal article
- review article
- Published by Wolters Kluwer Health in Journal of Nervous & Mental Disease
- Vol. 181 (6) , 345-350
- https://doi.org/10.1097/00005053-199306000-00002
Abstract
Sufficient data have accumulated to raise serious doubts about the integrity of the double-blind design that is presumed to shield psychotropic drug trials from bias and expectations. A major deficit in most drug trials has been the use of inert rather than active placebos. The deficiencies of the double-blind paradigm call for a questioning stance with respect to previous studies of psychotropic drug efficacy. Various possible ways of strengthening the double-blind paradigm are reviewed.Keywords
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