Fluorescence Signal Amplification by Cation Exchange in Ionic Nanocrystals
- 10 February 2009
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 48 (9) , 1588-1591
- https://doi.org/10.1002/anie.200805710
Abstract
Lighting-up time: A cation-exchange reaction releases thousands of divalent cations from nonfluorescent CdSe ionic crystals and triggers fluorescence from thousands of originally nonfluorescent Fluo-4 fluorophores to obtain a large fluorescence amplification (see picture) and a low detection limit in bioassays. The technique is fast, simple, with a large dye-to-reporter labeling ratio, and flexible in selection of nanocrystals and fluorophores.Keywords
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