Interleukin 6 mediated differentiation and rescue of cell redox in PC 12 cells exposed to ionizing radiation
- 15 May 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 364 (3) , 298-300
- https://doi.org/10.1016/0014-5793(95)00412-3
Abstract
The differentiation of PC12 cells to a neuron-like morphology was induced by ionizing radiation in the presence of serum. This effect was detectable at 5 grays (Gy) and reached a maximum at 10–20 Gy. Increases in the DNA binding activity of nuclear factor κB (NF-κB) and increased Interleukin 6 (IL-6) mRNA levels were observed at a dose of 15 Gy. Neutralization of supernatant IL-6 by the addition of anti-IL-6 antibody inhibited the neuronal differentiation and decreased cellular redox. Ionizing radiation and serum may act synergistically as neurotropic factorsKeywords
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