Equivalence of Thyroid Preparations

5 September 1980

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 244 (10) , 1095
https://doi.org/10.1001/jama.1980.03310100015015

Abstract

To the Editor.— In the report on nonequality of brand name T₄products by Jacobson et al, the rather dramatic differences in bioavailability as measured by the mean T₄concentration and free T₄index between Levothroid and Synthroid have not been shown in various studies we have done using both patients and healthy volunteers. In 1965 to 1966, we did a series of comparison studies using Levothroid and Synthroid. Seventy-five hypothyroid patients were treated with either preparation and maintained at a clinically euthyroid state for at least one month. At that time, determinations of protein-bound iodine (PBI) and serum triiodothyronine (T₃) uptake were done. Each patient then had therapy with the alternative brand at the same dosage given for at least one month, at which time the two laboratory determinations were again due. The results showed a mean PBI value in patients treated with Levothroid to

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