The effect of various antibacterial preparations on the in vitro morphology and chemotactic response of equine neutrophils

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Abstract
Two independent assay systems were used to study the effect of three antibacterial preparations on in vitro morphology and chemotaxis of equine neutrophils. Incubation of neutrophils with high (200 .mu.g/ml) and medium (20 .mu.g/ml) concentration of neomycin impaired their response to standard chemoattractants. Trimethoprim/sulfadoxine (0.4/2.0 .mu.g/ml-40/200 .mu.g/ml) and benzylpenicillin (0.25-25 .mu.g/ml) had no effect. Neutrophils collected from geldings 2 and 24 h after neomycin (5 mg/kg) administration had impaired responses to standard chemoattractants. Benzylpenicillin (13.2 mg/kg) had no effect.