Differential effects of DNA tumor virus nuclear oncogene products on adipocyte differentiation
- 11 May 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 215 (2) , 345-349
- https://doi.org/10.1016/0014-5793(87)80175-8
Abstract
We have introduced SV40 and polyoma large T antigen- and adenovirus-type 12 E1A genes into mouse 3T3-L1 preadipocyte cells to study the ability of various nuclear oncogene products to modulate cell differentiation. Clones expressing E1A products could differentiate into adipocytes faster than the control in spite of the absence of adipogenic inducers, as measured by the appearance of lipid droplets microscopically and by staining accumulated triglycerides with oil red O. However, clones expressing SV40 and polyoma large T antigens could not differentiate even if they were exposed to the inducers.Keywords
This publication has 14 references indexed in Scilit:
- Induction of c-Ha-ras transcription in rat cells by simian virus 40 large T antigen.Molecular and Cellular Biology, 1987
- Characterization of the chimeric SV40 large T antigen which has a membrane attachment sequence of polyoma virus middle T antigenVirology, 1986
- Recombinant retroviruses that transduce individual polyoma tumor antigens: effects on growth and differentiation.Proceedings of the National Academy of Sciences, 1986
- Cooperation of mitogenic growth factors with polyoma virus middle T antigen in transformation of secondary cultured rat cellsBiochemical and Biophysical Research Communications, 1986
- Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitmentNature, 1986
- Type beta transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts.Proceedings of the National Academy of Sciences, 1985
- Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell lineNature, 1985
- HeLa cell beta-tubulin gene transcription is stimulated by adenovirus 5 in parallel with viral early genes by an E1a-dependent mechanism.Molecular and Cellular Biology, 1984
- Activation of mouse genes in transformed cellsCell, 1983
- An established preadipose cell line and its differentiation in culture II. Factors affecting the adipose conversionCell, 1975