Stroke and Apolipoprotein E ε4 Are Independent Risk Factors for Cognitive Decline

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Abstract
Background and Purpose —Stroke and apolipoprotein E ε4 (ApoE ε4) are individually important risk factors for cognitive decline, including Alzheimer disease. It has been suggested that ApoE ε4 multiplies the risk for cognitive decline following stroke. In a population-based sample, using well-defined sensitive cognitive measures, this study investigates whether cognitive decline following stroke is worse for patients who carry the ApoE ε4 allele. Methods —Subjects were participants in the Longitudinal Aging Study Amsterdam (LASA). The sample consisted of 1224 subjects, aged 62 to 85 years, who participated in the 3-year follow-up examination and for whom ApoE and stroke data were complete. We assessed cognitive decline using the Mini-Mental State Examination, the Auditory Verbal Learning Test (memory: immediate and delayed recall), and the Coding Task (information processing speed). The effects of stroke and ApoE ε4 on cognitive decline were evaluated with ANOVA and multiple logistic regression analysis, adjusted for age, sex, education, and baseline cognition. Results —A synergistic effect modification for stroke and ApoE ε4 on cognitive decline was not observed. Unexpectedly, instead, stroke patients carrying the ε4 allele demonstrated a nonsignificantly lowered risk for Mini-Mental State Examination decline (OR=0.3; 95% CI 0.1 to 1.1). ApoE ε4 was associated with declines in information processing speed (OR=1.5; 95% CI 1.1 to 2.1) and small declines for immediate and delayed recall. Conclusions —Stroke and ApoE ε4 may impair cognition through distinct nonsynergistic mechanisms. The slowing of information processing speed for ApoE ε4 carriers was more evident than impairment in memory.
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