Gytochemical Effects of Substituted Pyrimidines on Psittacosis Virus.
- 1 December 1960
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 105 (3) , 476-478
- https://doi.org/10.3181/00379727-105-26146
Abstract
Cytochemical changes associated with psittacosis virus infection of tissue cultures were studied by acridine orange staining and fluorescence microscopy. Normal virus development was interrupted by the addition of 5-fluorouracil and 5-fluoroorotic acid which caused the accumulation of "Fraudulent" ribonucleic acid. It is suggested that the substituted pyrimidines interfered with development of intact virus through inhibition of protein synthesis. This was differentiated from the virus inhibitory effect of chlortetracycline.Keywords
This publication has 2 references indexed in Scilit:
- Histochemical differentiation of nucleic acids by means of induced fluorescenceExperimental Cell Research, 1956
- IDENTIFICATION OF CYTOPLASMIC BASOPHILIA (RIBONUCLEIC ACID) BY FLUORESCENCE MICROSCOPYJournal of Histochemistry & Cytochemistry, 1956