The Chemotherapy of Viral Infections

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Abstract
ATTEMPTS to develop clinically useful drugs for the prevention and treatment of viral infections have been faced by a variety of problems quite different from those encountered in the development of other types of antimicrobial compounds. Fundamental biologic differences between viruses and other infectious agents for which effective chemotherapy is available are, in good part, responsible for the difficulties and slow progress in the discovery of drugs that inhibit viral growth. Among these are strict dependence of viruses on living cells for replication, narrow limits between the capacity of a drug to suppress viral multiplication and to produce cellular injury . . .