Pathogenesis and Management of Acquired Haemophilia
- 1 January 1998
- journal article
- other
- Published by Taylor & Francis in Hematology
- Vol. 3 (3) , 181-192
- https://doi.org/10.1080/10245332.1998.11746390
Abstract
The development of auto-antibodies to factor VIII results in a severe bleeding disorder, which has a mortality of up to 22%. It is predominantly a disease of the elderly, and probably results from a failure of the mechanisms which normally maintain immunological unresponsiveness to FVIII. An increasingly large therapeutic armamentarium often enables bleeds to be treated effectively with coagulation factor concentrates (or occasionally, desmopressin) while an attempt is made to lower the concentration of the antibody by immunomodulation with intravenous immunoglobulin and immunosuppressive drugs. A consequence of the high cost of the coagulation factor concentrates and the not infrequent need to provide treatment over long periods of time is that such treatment often has serious resource implications.Keywords
This publication has 74 references indexed in Scilit:
- Factor VIII Inhibitors in Mild and Moderate-severity Haemophilia AThrombosis and Haemostasis, 1998
- Successful Treatment of Acquired Hemophilia with Oral Immunosuppressive TherapyAnnals of Internal Medicine, 1997
- 8 Inhibitors in congenital haemophiliaBailliere's Clinical Haematology, 1996
- Severe intracranial hemorrhage in a newborn infant with transplacental transfer of an acquired factor VIII:C inhibitorThe Journal of Pediatrics, 1995
- Lesson of the Week: Acquired haemophilia: an important but often unrecognised cause of bleeding in elderly peopleBMJ, 1995
- Post-Partum Factor VIII InhibitorsThrombosis and Haemostasis, 1995
- Use of porcine factor VIII in the treatment of patients with acquired hemophiliaBlood, 1993
- Acquired HemophiliaArchives of internal medicine (1960), 1987
- Corticosteroid Therapy for Acquired F VIII:C InhibitorsBritish Journal of Haematology, 1981
- Hemophilia-like Disease Following PregnancyBlood, 1953