Cimetidine in Gastro-Oesophageal Reflux

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Abstract
Fifteen-hour intraesophageal pH monitoring and symptom scores were used to compare the effect of cimetidine, 1 or 2 g daily, with placebo on patients with acid gastroesophageal reflux. Night pain and antacid consumption were reduced by cimetidine, but other symptoms did not show significant differences. Symptomatic improvement appeared greater in smokers than nonsmokers. Fifteen-hour intraesophageal pH measurements showed that the number of reflux episodes was reduced in the cimetidine-treated groups.