Regulatory Effect of Hydrocortisone on the in vitro Synthesis of IgE by Human Lymphocytes
- 1 January 1985
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 77 (4) , 413-415
- https://doi.org/10.1159/000233818
Abstract
The effect of different concentrations of hydrocortisone (HC) on the in vitro, pokeweed mitogendriven synthesis of IgG and IgE by human lymphocytes was studied. HC had the same modulatory action on the production of both immunoglobulins. Two different effects were observed: the first is enhancement of Ig synthesis by low concentrations of HC (10––7–10––4M), and the second is inhibition of synthesis by higher concentrations due to lymphocytoxic effect.Keywords
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