Suppression of contractile force in muscle fibers by antibody to myosin subfragment 2.
- 1 March 1988
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 85 (6) , 1849-1853
- https://doi.org/10.1073/pnas.85.6.1849
Abstract
Polyclonal antibody directed against the subfragment-2 region of myosin was purified by affinity chromatography. Skinned muscle fibers that had been preincubated with antibody were able to sustain only 7% of the active isometric force generated by control fibers. The effect of antibody on force production could not be accounted for by inhibition of ATP turnover.This publication has 15 references indexed in Scilit:
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