Association of HLA‐DR3 with human immune response to Lol p I and Lol p II allergens in allergic subjects

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Abstract
Associations between HLA type and IgE or IgG antibody (Ab) responses to two well-characterized, antigenetically non-crossreactive components of Lolium perenne (rye grass) pollen extract, Lol p I(Rye I) and Lol p II (Rye II) were studied in two groups of skin-test positive (ST +) Caucasoid adults. By both nonparametric and parametric statistical methods, significant associations were found between Ab responses to both Lol I and Lol II and the possession of HLA-DR3. In view of the well-known associations of both DR3 and B8 (which are in linkage disequilibrium) with many autoimmune disease, differences in anti-Lol I and anti-Lol II mean log [Ab] levels between B8+, DR3- vs B8-, DR3- subjects and B8+,DR3+ vs B8-, DR3+ subjects were investigated. No differences were found. Our data, along with recent RFLP and DNA sequence studies, suggest that an Ia molecule involved in immune recognition of a similar major Ia recognition site of both the Lol molecules may consist of a DR3.alpha.-.beta.I pair.