Classification of Hybridomas to Respiratory Syncytial Virus Glycoproteins

1 December 1982

journal article
research article
Published by Frontiers Media SA in Experimental Biology and Medicine

Vol. 171 (3) , 266-271
https://doi.org/10.3181/00379727-171-41509

Abstract

We have classified 28 hybridomas to the RS virus glycoproteins, VP66, VP84, by virus neutralization, RIP, and RIA tests. Without resorting to RIP, a combination of neutralization tests and RIA on BCH4 and RS/HO cells could be used to classify 79% of the hybridomas antibodies correctly. VP66 contains major determinants for virus neutralization since 11/13 hybridoma antibodies to this protein neutralized RS virus while 0/15 hybridoma antibodies to VP84 neutralized the virus.

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