Human papillomavirus type 6 E7 protein is a substrate in vitro of protein kinase C
- 15 December 1995
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 312 (3) , 667-670
- https://doi.org/10.1042/bj3120667
Abstract
The E7 proteins of ‘low-risk’ and ‘high-risk‘ human papillomaviruses (HPV) are phosphorylated by casein kinase II. In this study, we report that the ‘low-risk’ HPV 6 E7 protein, but not the ‘high-risk’ HPV 16 E7 protein, can be phosphorylated in vitro on threonine at amino acid position 7 by protein kinase C. This is the first example of a qualitative biochemical difference between the HPV 6 E7 and HPV 16 E7 proteins.Keywords
This publication has 27 references indexed in Scilit:
- Protein Kinase C Regulates Keratinocyte Transglutaminase (TGK) Gene Expression in Cultured Primary Mouse Epidermal Keratinocytes Induced to Terminally Differentiate by CalciumJournal of Investigative Dermatology, 1994
- A Casein Kinase Type II (CKII)-like Nuclear Protein Kinase Associates with, Phosphorylates, and Activates Topoisomerase IBiochemical Medicine and Metabolic Biology, 1993
- The Anomalous Electrophoretic Behavior of the Human Papillomavirus Type 16 E7 Protein Is Due to the High Content of Acidic Amino Acid ResiduesBiochemical and Biophysical Research Communications, 1993
- Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C.The Journal of cell biology, 1993
- Mutagenesis of human papillomavirus types 6 and 16 E7 open reading frames alters the electrophoretic mobility of the expressed proteinsJournal of General Virology, 1992
- The consensus sequences for cdc2 kinase and for casein kinase‐2 are mutually incompatible A study with peptides derived from the β‐subunit of casein kinase‐2FEBS Letters, 1992
- Identification of phosphorylation sites on murine nuclear lamin C by RP‐HPLC and microsequencingFEBS Letters, 1991
- Phosphorylation of transcriptional factors and cell-cycle-dependent proteins by casein kinase IICurrent Opinion in Cell Biology, 1991
- Relative enhancer activity and transforming potential of authentic human papillomavirus type 6 genomes from benign and malignant lesionsJournal of General Virology, 1991
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970