Abstract
Anatomic studies are of greatest value when carried out developmentally; only this approach can reveal what tissues and cells are primarily affected. Electron microscopy promises to make the studies of the morphology of viral infections more meaningful by relating the internal symptoms to the distribution of virus particles in the host tissues. Combined with histochemistry and use of labeled viruses, or virus precursors, electron microscopy should reveal virus-induced changes at the molecular level and thus provide a new dimension to the distinction between primary and secondary symptoms.