EFFECT OF GONADOTROPHIN ON OVARIAN AND UTERINE TRANSAMINASE ACTIVITY

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Abstract
The glutamic-pyruvic transaminase (GPT) activity in the ovary and uterus of rats was examined after serum and chorionic gonadotrophin stimulation. These gonadotrophins were found to increase considerably the GPT activity in the above mentioned tissues. This effect of gonadotrophins was tested with different doses of gonadotrophins, at increasing intervals after a single injection and under different physiological conditions (vitamin B6 deficiency, hypothyroidism and inanition), and subsequently compared with the effect of gonadotrophins on glutamic-oxalacetic transaminase (GOT). Such comparisons showed that these 2 enzymes behaved differently under all the experimental conditions investigated. The possible significance of the gonadotrophin stimulating effect in transaminase activity is discussed.