THE EFFECT OF TAURINE ON HIGH POTASSIUM‐ AND NORADRENALINE‐INDUCED CONTRACTION IN RABBIT EAR ARTERY

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Abstract
1 Intraluminal administration of taurine (40 mm) did not affect the contractile tone of rabbit isolated ear artery. 2 Taurine (10–80 mm) exerted a powerful concentration-dependent, vasodilator action in arteries contracted with high potassium medium. 3 In the same experimental conditions, the taurine analogues β-alanine and homotaurine, had no effect. 4 Taurine (40–80 mm) did not affect in a significant manner the tonic component of the noradrenaline (5 × 10−6 m)-induced contraction. 5 When noradrenaline (5 × 10−6 m) was followed by the administration of high potassium medium a further increase in intraluminal pressure was observed. Under these conditions taurine (40 mm) reversed specifically the component due to the high potassium medium.