Acute effects of diphenylhydantoin in relation to plasma levels: Behavioural and psychophysiological studies
- 1 May 1972
- journal article
- case report
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 2 (2) , 111-120
- https://doi.org/10.1017/s0033291700040599
Abstract
Synopsis: Two double-blind experiments are reported in which different doses of diphenylhydantoin were compared with placebo. Drug effects on tests, psychophysiological measures, and self-ratings of mood were studied in normal subjects and related to plasma levels of the drug and psychasthenic personality traits. Significant sedative effects were obtained in some self-rating variables. The combined effect in the objective psychological tests was significantly correlated (rank) to the plasma level in the higher dose experiment.Keywords
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