Prediction of strong antigenic determinant of seminalplasmin and ribonuclease from the amino acid sequence
- 12 January 2009
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 25 (2) , 197-199
- https://doi.org/10.1111/j.1399-3011.1985.tb02164.x
Abstract
It was previously reported that the antigenic determinants of a protein can be delineated by examining the average local hydrophilicity values along the peptide chain. This method was used to predict the strong antigenic determinants of 2 proteins, seminalplasmin and RNase, of known sequence. In the former case, the N-terminal segment 1-14 and in the latter case the segments 27-38 and 80-86, were predicted to possess the antigenic determinants of the 2 proteins. Experimental verification already exists for the former case.Keywords
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