ROLE OF FIBRIN FORMATION IN PATHOGENESIS OF BACTEREMIC SHOCK IN PRIMATE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 146  (4) , 535-540
Abstract
The role of intravascular fibrin formation in the pathogenesis of sepsis in the primate (baboon) was studied. Escherichia coli caused death in primates within 4-11 h as a result of microculatory failure and acidosis. Pretreatment with Arvin did not prolong the survival rate, probably because of an overloading of the RES with fibrin degradation products. This study does not support an obligatory role for intravascular coagulation or fibrin formation in primate sepsis. Vascular damage and malfunction, secondary to mediators released by platelets, leukocytes, red cells or Hageman factor were not ruled out.