Loss of quin 2 accompanies degranulation of mast cells
- 15 December 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 209 (2) , 169-174
- https://doi.org/10.1016/0014-5793(86)81105-x
Abstract
Stimulation of quin 2 loaded mast cells in the presence of 1 mM extracellular calcium produced a rapid and sustained increase in quin 2 fluorescence. This was accompanied by degranulation and the release of histamine. When Ca was replaced by EGTA or when Mn was present, a decrease in fluorescence accompanied degranulation. The increase in quin 2 fluorescence accompanying stimulation of mast cells appears to be due to the interaction of extracellular Ca with quin 2 associated with the secretory granule matrix released upon exocytosis.Keywords
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