EFFECT OF SUCRALFATE ON IBUPROFEN ABSORPTION IN NORMAL VOLUNTEERS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 3  (6) , 630-633
Abstract
The effect of the concurrent administration of sucralfate on the absorption of a single dose of ibuprofen was studied in 9 normal volunteers using a random crossover design. [Sucralfate, clinically effective in short-term treatment of duodenal peptic ulcer, is often administered concurrently with ibuprofen.] Each participant received a single 600-mg dose of ibuprofen for the control phase, and a 600-mg dose of ibuprofen following 5 g of sucralfate given in 1-g divided doses for the treatment phase. Blood samples were obtained at regular intervals for 12 h following the administration of ibuprofen, pharmacokinetic and statistical analyses were performed. Analysis of time to peak serum concentration, maximum serum concentration, elimination rate constant and half-life showed no significant difference between the control and treatment phases. Mean total area under the curve for ibuprofen decreased by 11.8% in the treatment phase, but this decrease was not statistically significant. The concurrent administration of sucralfate did not significantly alter the absorption of a single 600-mg dose of ibuprofen in healthy subjects.

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