Vascular volume changes following histamine release in the dog forelimb

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Abstract
In isolated dog forelimb preparations with constant blood flow, hemodynamic changes were determined. Vascular volume changes were estimated by red cells-Cr51 and albumin-I131 and by changes in limb volume. Recovery of the latter 2 indicators and Rb86Cl was determined. Net capillary filtration of fluid was determined. Measurements were made in group I: under control conditions; during vaso-dilation with Compound 48/80; and after sectioning of the brachial nerves during the infusion. In group II measurements were made under control conditions; after nerve sectioning; and during 48/80 infusion. Following vasodilation, vascular volume increased as determined by the indicators but not by the volume recorder. Capillary transfer increased and Rb86Cl recovery decreased. Nerve sectioning caused a further increase in vascular volume in 8 of the 12 dogs but a reduction in net capillary transfer and greater Rb86Cl recovery. Four preparations had a resistance increase, reduction in capillary transfer, and no change in Rb86Cl recovery. In group II, nerve sectioning caused a small increase in capillary transfer, no change in Rb86Cl recovery, and a small increase in vascular volume. Compound 48/80 caused a large increase in capillary transfer and vascular volume and reduction in Rb86Cl recovery. Compound 48/80 infusion caused an increase in capillary permeability.