Catalytic asymmetric synthesis of hydroxyketones by chemo- and enantio-selective alkylation of ketoaldehydes
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 9,p. 534-536
- https://doi.org/10.1039/c39890000534
Abstract
Optically active hydroxyketones [up to 93% enantiomeric excess (e.e.)] were obtained from the highly chemo- and enantio-selective alkylation of ketoaldehydes with dialkylzinc reagents using (2′S)-(+)-diphenyl(1′-methylpyrrolidin-2′-yl)methanol (DPMPM), or (1S,2R)-(–)-, and (1R,2S)-(+)-2-(N,N-dibutylamino)-1-phenylpropan-1-ol (N,N-dibutylnorephedrine)(DBNE) as chiral catalysts.Keywords
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