Reflex vascular responses in the finger to contralateral thermal stimuli during the normal menstrual cycle: a hormonal basis to Raynaud's phenomenon?

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Abstract
Raynaud''s phenomenon is a condition which primarily affects women and it must be assumed that hormonal influences are responsible. To further investigate this assumption the effect of cyclic sex hormone fluctuations on the digitial vascular reactivity of 10 normal young women was studied by the diagnostic techniques of thermal entrainment of finger blood flow and Doppler ultrasound mapping of the digital arteries. In the immediate pre-ovulatory period the results obtained were comparable with those found in patients with established Raynaud''s phenomenon, suggesting that estrogen has an important modulating effect in vivo on reflex peripheral vasomotor responses to thermal stimuli. Primary Raynaud''s phenomenon may represent an exaggerated response to estrogen.

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