Lymphocyte activation. 3. Binding sites for phytomitogens on lymphocyte subpopulations.

  • 1 March 1972
    • journal article
    • Vol. 10  (3) , 537-54
Abstract
The presence of binding sites for concanavalin A, phytohaemagglutinin and lentil mitogen on the surface of mouse B and T lymphocytes has been investigated in relation to the previously described mitogenic selectivity of these stimulants for T cells. Purified T or B or mixed T/B suspensions of cells have been analysed both for proportions of cells with affinity for phytomitogens and for the relative density of binding sites. In addition, the specificity of mitogens for simple saccharides has been investigated in relation to binding of the former to T and B cells.